Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.
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Authors
Eslam, Mohammed
Alkhouri, Naim
Vajro, Pietro
Baumann, Ulrich
Weiss, Ram
Socha, Piotr
Marcus, Claude
Lee, Way Seah
Kelly, Deirdre
Porta, Gilda
El-Guindi, Mohamed A
Alisi, Anna
Mann, Jake P
Mouane, Nezha
Baur, Louise A
Dhawan, Anil
George, Jacob
Publication Date
2021-10Journal Title
Lancet Gastroenterol Hepatol
ISSN
2468-1253
Publisher
Elsevier BV
Volume
6
Issue
10
Pages
864-873
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Eslam, M., Alkhouri, N., Vajro, P., Baumann, U., Weiss, R., Socha, P., Marcus, C., et al. (2021). Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.. Lancet Gastroenterol Hepatol, 6 (10), 864-873. https://doi.org/10.1016/S2468-1253(21)00183-7
Abstract
The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults. In this Viewpoint we, an international panel, propose an overarching framework for paediatric fatty liver diseases and an age-appropriate MAFLD definition based on sex and age percentiles. The framework recognises the possibility of other coexisting systemic fatty liver diseases in children. The new MAFLD diagnostic criteria provide paediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, and they align with a definition that is valid across the lifespan.
Keywords
Adolescent, Adult, Child, Consensus, Disease Progression, Female, Humans, Insulin Resistance, Interdisciplinary Communication, Male, Metabolic Syndrome, Non-alcoholic Fatty Liver Disease, Obesity, Prevalence, Prognosis, Randomized Controlled Trials as Topic, Risk Factors, Severity of Illness Index
Sponsorship
Wellcome Trust (204017/Z/16/Z)
Identifiers
External DOI: https://doi.org/10.1016/S2468-1253(21)00183-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334537
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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