Integrating adipocyte insulin signaling and metabolism in the multi-omics era.
Calejman, C Martinez
Trends Biochem Sci
MetadataShow full item record
Calejman, C. M., Doxsey, W., Fazakerley, D., & Guertin, D. (2022). Integrating adipocyte insulin signaling and metabolism in the multi-omics era.. Trends Biochem Sci https://doi.org/10.1016/j.tibs.2022.02.009
Insulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4 translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, and de novo lipogenesis. Adipocyte insulin resistance is an early indicator of type 2 diabetes in obesity, a worldwide health crisis. Thus, understanding the interplay between insulin signaling and central carbon metabolism pathways that maintains adipocyte function, blood glucose levels, and metabolic homeostasis is critical. While classically viewed through the lens of individual enzyme-substrate interactions, advances in mass spectrometry are beginning to illuminate adipocyte signaling and metabolic networks on an unprecedented scale, yet this is just the tip of the iceberg. Here, we review how 'omics approaches help to elucidate adipocyte insulin action in cellular time and space.
None from UK. NIH in USA and ANPCyT and Universidad de Buenos Aires in Argentina
Medical Research Council (MR/S007091/1)
Embargo Lift Date
External DOI: https://doi.org/10.1016/j.tibs.2022.02.009
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334573
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/