Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions
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Publication Date
2022-04-20Journal Title
RSC Medicinal Chemistry
ISSN
2632-8682
Publisher
Royal Society of Chemistry
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Leeper, F., Rudge, E. S., & Chan, A. H. (2022). Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions. RSC Medicinal Chemistry https://doi.org/10.1039/D1MD00297J
Abstract
Pyrophosphates have important functions in living systems and thus pyrophosphate-containing molecules and their more stable bisphosphonate analogues have the potential to be used as drugs for treating many diseases including cancer and viral infections. Both pyrophosphates and bisphosphonates are polyanionic at physiological pH and, whilst this is essential for their biological activity, it also limits their use as therapeutic agents. In particular, the high negative charge density of these compounds prohibits cell entry other than by endocytosis, prevents transcellular oral absorption and causes sequestration to bone. Therefore, prodrug strategies have been developed to temporarily disguise the charges of these compounds. This review examines the various systems that have been used to mask the phosphorus-containing moieties of pyrophosphates and bisphosphonates and also illustrates the utility of such prodrugs.
Sponsorship
Kwong Mei Medhealth
Embargo Lift Date
2023-12-25
Identifiers
External DOI: https://doi.org/10.1039/D1MD00297J
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334583
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