Drug delivery from a solid formulation during breastfeeding-A feasibility study with mothers and infants.
Whitehouse, Sophie L
Slater, Nigel KH
Public Library of Science (PLoS)
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Maier, T., Peirce, P., Baird, L., Whitehouse, S. L., Slater, N. K., & Beardsall, K. (2022). Drug delivery from a solid formulation during breastfeeding-A feasibility study with mothers and infants.. PLoS One, 17 (3) https://doi.org/10.1371/journal.pone.0264747
Funder: University of Cambridge WD Armstrong Trust
Funder: University of Cambridge Kurt Hahn Trust
Funder: Studienstiftung des Deutschen Volkes; funder-id: http://dx.doi.org/10.13039/501100004350
BACKGROUND: Breastfeeding is critical to health outcomes, particularly in low-resource settings where there is little access to clean water. For infants in their first twelve months of life, the delivery of medications is challenging, and use of oral syringes to deliver liquid formulations can pose both practical and emotional challenges. OBJECTIVE: To explore the potential to deliver medicine to infants via a solid formulation during breastfeeding. METHODS: Single center feasibility study within a tertiary level neonatal unit in the UK, involving twenty-six breastfeeding mother-infant dyads. A solid formulation of Vitamin B12 was delivered to infants during breastfeeding. Outcomes included the quantitative change in serum vitamin B12 and assessment of maternal expectations and experiences. RESULTS: Delivery of Vitamin B12 through a solid formulation that dissolved in human milk did not impair breastfeeding, and Vitamin B12 levels rose in all infants from a mean baseline (range) 533 pg/mL (236-925 pg/mL) to 1871 pg/mL (610-4981 pg/mL) at 6-8 hours post-delivery. Mothers described the surprising ease of 'drug' delivery, with 85% reporting a preference over the use of syringes. CONCLUSIONS: Solid drug formulations can be delivered during breastfeeding and were preferred by mothers over the delivery of liquid formulations via a syringe.
Research Article, People and places, Medicine and health sciences, Physical sciences, Biology and life sciences, Social sciences
External DOI: https://doi.org/10.1371/journal.pone.0264747
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334676