Sequential enhancer state remodelling defines human germline competence and specification
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Peer-reviewed
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Article
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Abstract
Germline-soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell models recapitulating gastrulation.
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Keywords
Animals, Cell Differentiation, Embryonic Development, Endoderm, Gastrulation, Gene Expression Regulation, Developmental, Germ Cells, Humans, Mammals
Journal Title
Nature Cell Biology
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Journal ISSN
1465-7392
1476-4679
1476-4679
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Publisher
Nature Research
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Sponsorship
Wellcome Trust (109146/Z/15/Z)
Wellcome Trust (096738/Z/11/Z)
Wellcome Trust (203831/Z/16/Z)
Wellcome Trust (209475/Z/17/Z)
Medical Research Council (MR/P009948/1)
BBSRC (BB/T01346X/1)
Wellcome Trust (096738/Z/11/Z)
Wellcome Trust (203831/Z/16/Z)
Wellcome Trust (209475/Z/17/Z)
Medical Research Council (MR/P009948/1)
BBSRC (BB/T01346X/1)
Wellcome Trust PhD studentship RG86341/PRZI/045 Aracely Castillo-Venzor
Wellcome Trust PhD studentship (109146/Z/15/Z) Dawei Sun