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The evolution of mendelian randomization for investigating drug effects.

Published version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/334718

Repository DOI

https://doi.org/10.17863/CAM.82136
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Published version (285.64 KB)

Type

Article

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Authors

Gill, Dipender  ORCID logo  https://orcid.org/0000-0001-7312-7078
Burgess, Stephen  ORCID logo  https://orcid.org/0000-0001-5365-8760

Abstract

Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied inhibition of antihypertensive drug targets and risk of common cancer subtypes using Mendelian randomization.

Description

Keywords

Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Colorectal Neoplasms, Genetic Variation, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Risk Factors

Journal Title

PLoS Med

Conference Name

Journal ISSN

1549-1277
1549-1676

Volume Title

19

Publisher

Public Library of Science (PLoS)

Publisher DOI

https://doi.org/10.1371/journal.pmed.1003898

Rights and licensing

Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (RG/18/13/33946)

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