The evolution of mendelian randomization for investigating drug effects.

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Authors
  Gill, Dipender
  Burgess, Stephen
Publication Date
2022-02
Journal Title
PLoS Med
ISSN
1549-1277
Publisher
Public Library of Science (PLoS)
Volume
19
Issue
2
Language
eng
Type
Article
This Version
VoR
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Citation
Gill, D., & Burgess, S. (2022). The evolution of mendelian randomization for investigating drug effects.. PLoS Med, 19 (2) https://doi.org/10.1371/journal.pmed.1003898
Abstract
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied inhibition of antihypertensive drug targets and risk of common cancer subtypes using Mendelian randomization.
Keywords
Humans, Colorectal Neoplasms, Antihypertensive Agents, Angiotensin-Converting Enzyme Inhibitors, Risk Factors, Blood Pressure, Genetic Variation, Genome-Wide Association Study, Mendelian Randomization Analysis
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
Identifiers
PMC8812877, 35113864
External DOI: https://doi.org/10.1371/journal.pmed.1003898
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334718
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International