Locus coeruleus in the pathogenesis of Alzheimer's disease: A systematic review.
Authors
Chen, Yuqing
Chen, Teng
Hou, Ruihua
Publication Date
2022Journal Title
Alzheimers Dement (N Y)
ISSN
2352-8737
Publisher
Wiley
Volume
8
Issue
1
Language
en
Type
Article
This Version
AO
VoR
Metadata
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Chen, Y., Chen, T., & Hou, R. (2022). Locus coeruleus in the pathogenesis of Alzheimer's disease: A systematic review.. Alzheimers Dement (N Y), 8 (1) https://doi.org/10.1002/trc2.12257
Abstract
The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic depletion, evidence indicates extensive LC degeneration as its earliest pathological marker. The current study aimed to systematically evaluate current evidence investigating the role of the LC in the pathogenesis of AD. A systematic search of the literature was performed on electronic databases including PubMed and Web of Science. Twelve animal, human post mortem, and human imaging studies were included in this review. Screening, data extraction, and quality assessment were undertaken following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for preferred reporting of systematic reviews. Significant associations were identified between LC changes and cognitive decline. Significant reductions in fiber density, neuronal number, and LC volume were seen to correlate with other pathological degenerative markers. Current evidence indicates an important role of the LC in pathogenesis of AD and suggests its potential in both diagnosis and treatment of AD. This systematic review advances our understanding of the role of the LC in AD by synthesizing available evidence, identifying research gaps, highlighting methodological challenges, and making recommendations for future work.
Keywords
ALTERNATE FORMAT RESEARCH ARTICLE, Alzheimer's disease, locus coeruleus, neuromelanin‐sensitive magnetic resonance imaging, noradrenaline, norepinephrine, systematic review
Identifiers
trc212257
External DOI: https://doi.org/10.1002/trc2.12257
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334729
Rights
Licence:
http://creativecommons.org/licenses/by-nc-nd/4.0/
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