Sepsis-3 criteria in AmsterdamUMCdb: open-source code implementation
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Publication Date
2022-03-15Journal Title
Gigabyte
ISSN
2709-4715
Publisher
GigaScience Press
Volume
2022
Pages
1-7
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Edinburgh, T., Eglen, S. J., Thoral, P., Elbers, P., & Ercole, A. (2022). Sepsis-3 criteria in AmsterdamUMCdb: open-source code implementation. Gigabyte, 2022 1-7. https://doi.org/10.46471/gigabyte.45
Abstract
Sepsis is a major healthcare problem with substantial mortality and a common reason for admission to the intensive care
unit (ICU). For this reason, the management of sepsis is an important area of ICU research. A number of large-scale,
freely-accessible ICU databases are available for observational research and the robust identification of septic patients in
such data sets is crucial for research purposes, particularly for comparative studies between critical care sub-populations
which may vary around the world. However, data structures are poorly standardised due to inevitable variances in
clinical electronic health record system vendor and implementation as well as research database design choices. Robust
and well-documented cohort selection (such as patients with sepsis) is crucial for reproducible research. In this work,
we operationalise the Sepsis-3 definition on the AmsterdamUMCdb, a recently published large European ICU database,
publishing open-access code for wider use by critical care researchers. This is the Author Accepted Manuscript, accepted
after peer review by GigaByte.
Sponsorship
EPSRC (2089662)
Engineering and Physical Sciences Research Council (EP/S515334/1)
Identifiers
External DOI: https://doi.org/10.46471/gigabyte.45
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335078
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