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dc.contributor.authorTörn, Carina
dc.contributor.authorLiu, Xiang
dc.contributor.authorOnengut-Gumuscu, Suna
dc.contributor.authorCounts, Kevin M
dc.contributor.authorMoreno, Jose Leonardo
dc.contributor.authorRemedios, Cassandra L
dc.contributor.authorChen, Wei-Min
dc.contributor.authorLeFaive, Jonathon
dc.contributor.authorButterworth, Martha D
dc.contributor.authorAkolkar, Beena
dc.contributor.authorKrischer, Jeffrey P
dc.contributor.authorLernmark, Åke
dc.contributor.authorRewers, Marian
dc.contributor.authorShe, Jin-Xiong
dc.contributor.authorToppari, Jorma
dc.contributor.authorZiegler, Anette-Gabriele
dc.contributor.authorRatan, Aakrosh
dc.contributor.authorSmith, Albert V
dc.contributor.authorHagopian, William A
dc.contributor.authorRich, Stephen S
dc.contributor.authorParikh, Hemang M
dc.contributor.authorTEDDY Study Group
dc.date.accessioned2022-03-17T10:04:36Z
dc.date.available2022-03-17T10:04:36Z
dc.date.issued2022-03-16
dc.date.submitted2021-10-26
dc.identifier.issn2045-2322
dc.identifier.others41598-022-08058-7
dc.identifier.other8058
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335093
dc.descriptionFunder: Lund University
dc.description.abstractThe Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/114
dc.subject/631/208
dc.subject/692/163
dc.subjectarticle
dc.titleTelomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.
dc.typeArticle
dc.date.updated2022-03-17T10:04:35Z
prism.issueIdentifier1
prism.publicationNameSci Rep
prism.volume12
dc.identifier.doi10.17863/CAM.82535
dcterms.dateAccepted2022-03-01
rioxxterms.versionofrecord10.1038/s41598-022-08058-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idNational Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) (U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829)
cam.issuedOnline2022-03-16


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