The Potential of Photoacoustic Imaging in Radiation Oncology
Authors
Lefebvre, Thierry L.
Brown, Emma
Hacker, Lina
Else, Thomas
Oraiopoulou, Mariam-Eleni
Tomaszewski, Michal R.
Jena, Rajesh
Bohndiek, Sarah E.
Publication Date
2022-03-03Journal Title
Frontiers in Oncology
Publisher
Frontiers Media S.A.
Volume
12
Language
en
Type
Other
This Version
VoR
Metadata
Show full item recordCitation
Lefebvre, T. L., Brown, E., Hacker, L., Else, T., Oraiopoulou, M., Tomaszewski, M. R., Jena, R., & et al. (2022). The Potential of Photoacoustic Imaging in Radiation Oncology. [Other]. https://doi.org/10.3389/fonc.2022.803777
Abstract
Radiotherapy is recognized globally as a mainstay of treatment in most solid tumors and is essential in both curative and palliative settings. Ionizing radiation is frequently combined with surgery, either preoperatively or postoperatively, and with systemic chemotherapy. Recent advances in imaging have enabled precise targeting of solid lesions yet substantial intratumoral heterogeneity means that treatment planning and monitoring remains a clinical challenge as therapy response can take weeks to manifest on conventional imaging and early indications of progression can be misleading. Photoacoustic imaging (PAI) is an emerging modality for molecular imaging of cancer, enabling non-invasive assessment of endogenous tissue chromophores with optical contrast at unprecedented spatio-temporal resolution. Preclinical studies in mouse models have shown that PAI could be used to assess response to radiotherapy and chemoradiotherapy based on changes in the tumor vascular architecture and blood oxygen saturation, which are closely linked to tumor hypoxia. Given the strong relationship between hypoxia and radio-resistance, PAI assessment of the tumor microenvironment has the potential to be applied longitudinally during radiotherapy to detect resistance at much earlier time-points than currently achieved by size measurements and tailor treatments based on tumor oxygen availability and vascular heterogeneity. Here, we review the current state-of-the-art in PAI in the context of radiotherapy research. Based on these studies, we identify promising applications of PAI in radiation oncology and discuss the future potential and outstanding challenges in the development of translational PAI biomarkers of early response to radiotherapy.
Keywords
Oncology, photoacoustic (optoacoustic) imaging, radiation oncology, radiotherapy, quantitative imaging biomarker, image guidance, translational research
Identifiers
External DOI: https://doi.org/10.3389/fonc.2022.803777
This record's DOI: https://doi.org/10.17863/CAM.82550
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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