Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus.
Authors
Milczak, Andrzej
Winiarczyk, Dagmara
Winiarczyk, Stanisław
Bochyńska, Diana
Adaszek, Łukasz
Winiarczyk, Mateusz
Lechowski, Roman
Publication Date
2022-03-19Journal Title
BMC Vet Res
ISSN
1746-6148
Publisher
Springer Science and Business Media LLC
Volume
18
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Milczak, A., Winiarczyk, D., Winiarczyk, S., Bochyńska, D., Adaszek, Ł., Winiarczyk, M., & Lechowski, R. (2022). Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus.. BMC Vet Res, 18 (1) https://doi.org/10.1186/s12917-022-03179-7
Abstract
BACKGROUND: Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evaluate the levels of the selected plasma haemostatic parameters in dogs suffering from diabetes. The study group consisted of 20 dogs meeting all the inclusion criteria, with fasting glycaemia exceeding 11.1 mmol/l. The control group consisted of 15 healthy dogs presented for routine examination. An evaluation of the prothrombin time (PT); and fibrinogen, D-dimer and antithrombin III (ATIII) levels was performed. RESULTS: Except for ATIII activity, the haemostatic parameter differences were not statistically significant. High values of ATIII activity were observed in 90% of diabetic dogs. On average, the values amounted to 166.6% and were 31.4% higher than those in the control group. The ATIII activity in the diabetic group was significantly higher than that in the control group (p = 0.0004). CONCLUSIONS: Here, we report elevated levels of ATIII in diabetic dogs. This finding may suggest the protective role of ATIII against potential thrombotic events. However, the exact role of ATIII in dog diabetes remains unclear.
Keywords
Research, Antithrombin III, Canine diabetes, Diabetes, Thrombosis, Blood coagulation
Identifiers
s12917-022-03179-7, 3179
External DOI: https://doi.org/10.1186/s12917-022-03179-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335226
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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