Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect.
Authors
Sasaki, Daisuke
Abe, Jiro
Takeda, Atsuhito
Harashima, Hideyoshi
Yamada, Yuma
Publication Date
2022-03-22Journal Title
Sci Rep
ISSN
2045-2322
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Sasaki, D., Abe, J., Takeda, A., Harashima, H., & Yamada, Y. (2022). Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect.. Sci Rep, 12 (1) https://doi.org/10.1038/s41598-022-08583-5
Abstract
Given the potential for myocardial stem cell transplantation as a promising treatment for heart failure, numerous clinical trials have been conducted and its usefulness has been clearly confirmed. However, the low rate of engraftment of transplanted cells has become a clinical problem, and this needs to be improved in the case of transplanting cells to the heart. To address this issue, we report on attempts to prepare mitochondria-activated stem cells (MITO cells) for use in transplantation. MITO cells, which is cardiac progenitor cells (CPCs) activated by the mitochondrial delivery of resveratrol with an anti-oxidant and mitochondrial activation effects were successfully prepared using a mitochondrial targeting nanocarrier (MITO-Porter). The purpose of this study was to validate the therapeutic effect of cell transplantation by the MITO cells using a mouse model of myocardial ischemia-reperfusion. Mouse CPCs were used as transplanted cells. The transplantation of CPCs and MITO cells were conducted after myocardial ischemia-reperfusion, and the therapeutic effect was determined. The MITO cells transplanted group showed increase in postoperative weight gain, improve cardiac function and inhibition of fibrosis compared to the non-transplanted group and the CPC group. The transplantation of MITO cells to the ischemic myocardium showed a stronger transplantation effect compared to conventional CPC transplantation.
Keywords
Article, /639/925/350, /639/925/352, /692/4019, /631/154/152, /631/80/642/333, article
Sponsorship
Ministry of Education, Culture, Sports, Science and Technology (17H02094)
Japan Science and Technology Agency (JPMJFR203X)
Identifiers
s41598-022-08583-5, 8583
External DOI: https://doi.org/10.1038/s41598-022-08583-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335372
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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