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dc.contributor.authorSasaki, Daisuke
dc.contributor.authorAbe, Jiro
dc.contributor.authorTakeda, Atsuhito
dc.contributor.authorHarashima, Hideyoshi
dc.contributor.authorYamada, Yuma
dc.date.accessioned2022-03-28T19:04:27Z
dc.date.available2022-03-28T19:04:27Z
dc.date.issued2022-03-22
dc.date.submitted2021-12-20
dc.identifier.issn2045-2322
dc.identifier.others41598-022-08583-5
dc.identifier.other8583
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335372
dc.description.abstractGiven the potential for myocardial stem cell transplantation as a promising treatment for heart failure, numerous clinical trials have been conducted and its usefulness has been clearly confirmed. However, the low rate of engraftment of transplanted cells has become a clinical problem, and this needs to be improved in the case of transplanting cells to the heart. To address this issue, we report on attempts to prepare mitochondria-activated stem cells (MITO cells) for use in transplantation. MITO cells, which is cardiac progenitor cells (CPCs) activated by the mitochondrial delivery of resveratrol with an anti-oxidant and mitochondrial activation effects were successfully prepared using a mitochondrial targeting nanocarrier (MITO-Porter). The purpose of this study was to validate the therapeutic effect of cell transplantation by the MITO cells using a mouse model of myocardial ischemia-reperfusion. Mouse CPCs were used as transplanted cells. The transplantation of CPCs and MITO cells were conducted after myocardial ischemia-reperfusion, and the therapeutic effect was determined. The MITO cells transplanted group showed increase in postoperative weight gain, improve cardiac function and inhibition of fibrosis compared to the non-transplanted group and the CPC group. The transplantation of MITO cells to the ischemic myocardium showed a stronger transplantation effect compared to conventional CPC transplantation.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/639/925/350
dc.subject/639/925/352
dc.subject/692/4019
dc.subject/631/154/152
dc.subject/631/80/642/333
dc.subjectarticle
dc.titleTransplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect.
dc.typeArticle
dc.date.updated2022-03-28T19:04:26Z
prism.issueIdentifier1
prism.publicationNameSci Rep
prism.volume12
dc.identifier.doi10.17863/CAM.82801
dcterms.dateAccepted2022-03-10
rioxxterms.versionofrecord10.1038/s41598-022-08583-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idMinistry of Education, Culture, Sports, Science and Technology (17H02094)
pubs.funder-project-idJapan Science and Technology Agency (JPMJFR203X)
cam.issuedOnline2022-03-22


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