Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.
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Authors
Gallagher, Eileen
Publication Date
2022-09-13Journal Title
J Infect Dis
ISSN
0022-1899
Publisher
Oxford University Press (OUP)
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Nyberg, T., Harman, K., Zaidi, A., Seaman, S. R., Andrews, N., Nash, S. G., Charlett, A., et al. (2022). Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.. J Infect Dis https://doi.org/10.1093/infdis/jiac063
Description
Funder: NIHR Health Protection Unit in Behavioural Science and Evaluation
Abstract
To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77-.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81-.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71-1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages.
Keywords
Mortality, Hospitalisation, Covid-19, Sars-cov-2, Ay.4.2, Vui-21oct-01
Sponsorship
UKRI Medical Research Council (MC_UU_00002/11; MC_UU_00002/10); MRC UKRI/DHSC NIHR COVID-19 rapid response call (MC_PC_19074); NIHR Health Protection Unit in Behavioural Science and Evaluation; NIHR Cambridge Biomedical Research Centre (BRC-1215-20014)
Funder references
MRC (unknown)
MRC (MC_PC 19074)
National Institute for Health Research (NIHR) (via University of Bristol) (200877 2020 - 245)
National Institute for Health Research (IS-BRC-1215-20014)
Identifiers
35184201, PMC8903446
External DOI: https://doi.org/10.1093/infdis/jiac063
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335385
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