High-Refractive-Index Chip with Periodically Fine-Tuning Gratings for Tunable Virtual-Wavevector Spatial Frequency Shift Universal Super-Resolution Imaging.
Kaminski, Clemens F
Adv Sci (Weinh)
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Tang, M., Han, Y., Ye, D., Zhang, Q., Pang, C., Liu, X., Shen, W., et al. (2022). High-Refractive-Index Chip with Periodically Fine-Tuning Gratings for Tunable Virtual-Wavevector Spatial Frequency Shift Universal Super-Resolution Imaging.. Adv Sci (Weinh), 9 (9) https://doi.org/10.1002/advs.202103835
Funder: Zhejiang University Education Foundation Global Partnership Fund
Funder: Open Foundation of the State Key Laboratory of Modern Optical Instrumentation
Funder: Zhejiang University Micro‐Nano Fabrication Center
Continued research in fields such as materials science and biomedicine requires the development of a super-resolution imaging technique with a large field of view (FOV) and deep subwavelength resolution that is compatible with both fluorescent and nonfluorescent samples. Existing on-chip super-resolution methods exclusively focus on either fluorescent or nonfluorescent imaging, and, as such, there is an urgent requirement for a more general technique that is capable of both modes of imaging. In this study, to realize labeled and label-free super-resolution imaging on a single scalable photonic chip, a universal super-resolution imaging method based on the tunable virtual-wavevector spatial frequency shift (TVSFS) principle is introduced. Using this principle, imaging resolution can be improved more than threefold over the diffraction limit of a linear optical system. Here, diffractive units are fabricated on the chip's surface to provide wavevector-variable evanescent wave illumination, enabling tunable spatial frequency shifts in the Fourier space. A large FOV and resolutions of λ/4.7 and λ/7.1 were achieved for label-free and fluorescently labeled samples using a gallium phosphide (GaP) chip. With its large FOV, compatibility with different imaging modes, and monolithic integration, the proposed TVSFS chip may advance fields such as cell engineering, precision industry inspection, and chemical research.
Research Article, Research Articles, field of view, label‐free, super‐resolution chips, tunable virtual‐wavevector spatial frequency shift
National Natural Science Foundation of China (61822510, 61735017, 62020106002, 31901059, 62005250)
National Key Research and Development Program of China (2018YFE0119000)
External DOI: https://doi.org/10.1002/advs.202103835
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335606