The why and how of adaptive immune responses in ischemic cardiovascular disease.
Publication Date
2022-05Journal Title
Nat Cardiovasc Res
ISSN
2731-0590
Publisher
Springer Science and Business Media LLC
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Mallat, Z., & Binder, C. J. (2022). The why and how of adaptive immune responses in ischemic cardiovascular disease.. Nat Cardiovasc Res https://doi.org/10.1038/s44161-022-00049-1
Abstract
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide. Most therapeutic approaches target traditional risk factors but ignore the fundamental role of the immune system. This is a huge unmet need. Recent evidence indicates that reducing inflammation may limit cardiovascular events. However, the concomitant increase in the risk of lifethreatening infections is a major drawback. In this context, targeting adaptive immunity could constitute a highly effective and safer approach. In this Review, we address the why and how of the immuno-cardiovascular unit, in health and in atherosclerotic disease. We review and discuss fundamental mechanisms that ensure immune tolerance to cardiovascular tissue, and examine how their disruption promotes disease progression. We identify promising strategies to manipulate the adaptive immune system for patient benefit, including novel biologics and RNA-based vaccination strategies. Finally, we advocate for establishing a molecular classification of atherosclerosis as an important milestone in our quest to radically change the understanding and treatment of atherosclerotic disease.
Sponsorship
Medical Research Council (MR/N028015/1)
British Heart Foundation (CH/10/001/27642)
British Heart Foundation (SP/F/20/150010)
British Heart Foundation (RE/18/1/34212)
Identifiers
External DOI: https://doi.org/10.1038/s44161-022-00049-1
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335690
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