Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
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Liu, X., Jin, S., Hu, S., Li, R., Pan, H., Liu, Y., Lai, P., et al. (2022). Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.. Nature communications, 13 (1) https://doi.org/10.1038/s41467-022-28799-3
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis and bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher the intra-tumor and inter-lesion diversity of CTCL patients and propose a multi-step tumor evolution model. We further establish a subtyping scheme based on the molecular features of malignant T cells and their pro-tumorigenic microenvironments: the T<sub>CyEM</sub> group, demonstrating a cytotoxic effector memory T cell phenotype, shows more M2 macrophages infiltration, while the T<sub>CM</sub> group, featured by a central memory T cell phenotype and adverse patient outcome, is infiltrated by highly exhausted CD8<sup>+</sup> reactive T cells, B cells and Tregs with suppressive activities. Our results establish a solid basis for understanding the nature of CTCL and pave the way for future precision medicine for CTCL patients.
External DOI: https://doi.org/10.1038/s41467-022-28799-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335724
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/