Antigenic evolution of dengue viruses over multiple decades
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Authors
Katzelnick, Leah
Coello Escoto, Ana
Huang, Angkana
Garcia-Carreras, Bernardo
Chowdhury, Nayeem
Maljkovic Berry, Irina
Chavez, Chris
Buchy, Philippe
Duong, Veasna
Dussart, Philippe
Gromowski, Gregory
Macareo, Louis
Thaisomboonsuk, Butsaya
Fernandez, Stefan
Jarman, Richard
Whitehead, Stephen
Cummings, Derek
Publication Date
2021Journal Title
Science
ISSN
0002-9637
Publisher
American Association for the Advancement of Science
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Katzelnick, L., Coello Escoto, A., Huang, A., Garcia-Carreras, B., Chowdhury, N., Maljkovic Berry, I., Chavez, C., et al. (2021). Antigenic evolution of dengue viruses over multiple decades. Science https://doi.org/10.1126/science.abk0058
Abstract
Infection with one of the dengue viruses 1-4 (DENV1-4) induces protective antibodies to homotypic infection. However, an exceptional feature of dengue viruses is that they can use preexisting heterotypic antibodies to infect Fcγ receptor-bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype using 1,944 sequenced isolates from Bangkok, Thailand between 1994-2014 (n=348) in comparison to regional and global DENV antigenic diversity (n=64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes became more similar, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a tradeoff in within versus between serotype antigenic change, whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.
Sponsorship
NIAID-NIH Centers of Excellence for Influenza Research and Surveillance contract HHSN272201400008C
ERC 804744
Funder references
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-0513/HHSN272201400008C)
National Institutes of Health (NIH) (via University of Florida) (UFDSP00011558)
European Commission Horizon 2020 (H2020) ERC (804744)
Identifiers
External DOI: https://doi.org/10.1126/science.abk0058
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336108
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