The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective.
View / Open Files
Authors
Kim, Cara Lynn
Cruz Espinoza, Ligia Maria
Vannice, Kirsten S
Rakotozandrindrainy, Raphaël
Teferi, Mekonnen
Lunguya, Octavie
Publication Date
2022Journal Title
Res Rep Trop Med
ISSN
1179-7282
Publisher
Informa UK Limited
Volume
13
Pages
1-9
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Kim, C. L., Cruz Espinoza, L. M., Vannice, K. S., Tadesse, B. T., Owusu-Dabo, E., Rakotozandrindrainy, R., Jani, I. V., et al. (2022). The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective.. Res Rep Trop Med, 13 1-9. https://doi.org/10.2147/RRTM.S282461
Abstract
While typhoid fever has largely been eliminated in high-income regions which have developed modern water, sanitation, and hygiene facilities, it remains a significant public health burden resulting in morbidity and mortality among millions of individuals in resource-constrained settings. Prevention and control efforts are needed that integrate several high-impact interventions targeting facilities and infrastructure, including those addressing improvements in sanitation, access to safe water, and planned urbanization, together with parallel efforts directed at effective strategies for use of typhoid conjugate vaccines (TCV). The use of TCVs is a critical tool with the potential of having a rapid impact on typhoid fever disease burden; their introduction will also serve as an important strategy to combat evolving antimicrobial resistance to currently available typhoid fever treatments. Well-designed epidemiological surveillance studies play a critical role in establishing the need for, and monitoring the impact of, typhoid fever control and prevention strategies implemented by public health authorities. Here, we present a perspective based on a narrative review of the impact of typhoid fever on morbidity and mortality in sub-Saharan Africa and discuss ongoing surveillance activities and the role of vaccination in prevention and control efforts.
Keywords
Mortality, Antimicrobial resistance, Sub-Saharan Africa, Burden, Typhoid, Conjugate-Vaccine
Identifiers
35308424, PMC8932916
External DOI: https://doi.org/10.2147/RRTM.S282461
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336293
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk