Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Large-Scale Study of 35,193 Blood Donors Conducted between June 2020 and September 2021.
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Authors
Siller, Anita
Seekircher, Lisa
Wachter, Gregor A
Astl, Manfred
Pfeifer, Bernhard
Gaber, Manfred
Schennach, Harald
Publication Date
2022-03-09Journal Title
Viruses
ISSN
1999-4915
Publisher
MDPI AG
Volume
14
Issue
3
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Siller, A., Seekircher, L., Wachter, G. A., Astl, M., Tschiderer, L., Pfeifer, B., Gaber, M., et al. (2022). Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Large-Scale Study of 35,193 Blood Donors Conducted between June 2020 and September 2021.. Viruses, 14 (3) https://doi.org/10.3390/v14030568
Abstract
There is uncertainty about the seroprevalence of anti-SARS-CoV-2 antibodies in the general population of Austria and about the waning of antibodies over time. We conducted a seroepidemiological study between June 2020 and September 2021, enrolling blood donors aged 18-70 years across Tyrol, Austria (participation rate: 84.0%). We analyzed serum samples for antibodies against the spike or the nucleocapsid proteins of SARS-CoV-2. We performed a total of 47,363 samples taken from 35,193 individuals (median age, 43.1 years (IQR: 29.3-53.7); 45.3% women; 10.0% with prior SARS-CoV-2 infection). Seroprevalence increased from 3.4% (95% CI: 2.8-4.2%) in June 2020 to 82.7% (95% CI: 81.4-83.8%) in September 2021, largely due to vaccination. Anti-spike IgG seroprevalence was 99.6% (95% CI: 99.4-99.7%) among fully vaccinated individuals, 90.4% (95% CI: 88.8-91.7%) among unvaccinated individuals with prior infection and 11.5% (95% CI: 10.8-12.3%) among unvaccinated individuals without known prior infection. Anti-spike IgG levels were reduced by 44.0% (95% CI: 34.9-51.7%) at 5-6 months compared with 0-3 months after infection. In fully vaccinated individuals, they decreased by 31.7% (95% CI: 29.4-33.9%) per month. In conclusion, seroprevalence in Tyrol increased to 82.7% in September 2021, with the bulk of seropositivity stemming from vaccination. Antibody levels substantially and gradually declined after vaccination or infection.
Keywords
Blood donors, Seroprevalence, Sars-cov-2, Anti-n Igg, Anti-s Igg, Humans, Immunoglobulin G, Seroepidemiologic Studies, Adolescent, Adult, Aged, Middle Aged, Blood Donors, Austria, Female, Male, Young Adult, COVID-19, SARS-CoV-2
Sponsorship
Tirol Kliniken GmbH (Not available)
Land Tirol (Not available)
Identifiers
35336975, PMC8954543
External DOI: https://doi.org/10.3390/v14030568
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336438
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