Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Large-Scale Study of 35,193 Blood Donors Conducted between June 2020 and September 2021.
Wachter, Gregor A
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Siller, A., Seekircher, L., Wachter, G. A., Astl, M., Tschiderer, L., Pfeifer, B., Gaber, M., et al. (2022). Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Large-Scale Study of 35,193 Blood Donors Conducted between June 2020 and September 2021.. Viruses, 14 (3) https://doi.org/10.3390/v14030568
There is uncertainty about the seroprevalence of anti-SARS-CoV-2 antibodies in the general population of Austria and about the waning of antibodies over time. We conducted a seroepidemiological study between June 2020 and September 2021, enrolling blood donors aged 18-70 years across Tyrol, Austria (participation rate: 84.0%). We analyzed serum samples for antibodies against the spike or the nucleocapsid proteins of SARS-CoV-2. We performed a total of 47,363 samples taken from 35,193 individuals (median age, 43.1 years (IQR: 29.3-53.7); 45.3% women; 10.0% with prior SARS-CoV-2 infection). Seroprevalence increased from 3.4% (95% CI: 2.8-4.2%) in June 2020 to 82.7% (95% CI: 81.4-83.8%) in September 2021, largely due to vaccination. Anti-spike IgG seroprevalence was 99.6% (95% CI: 99.4-99.7%) among fully vaccinated individuals, 90.4% (95% CI: 88.8-91.7%) among unvaccinated individuals with prior infection and 11.5% (95% CI: 10.8-12.3%) among unvaccinated individuals without known prior infection. Anti-spike IgG levels were reduced by 44.0% (95% CI: 34.9-51.7%) at 5-6 months compared with 0-3 months after infection. In fully vaccinated individuals, they decreased by 31.7% (95% CI: 29.4-33.9%) per month. In conclusion, seroprevalence in Tyrol increased to 82.7% in September 2021, with the bulk of seropositivity stemming from vaccination. Antibody levels substantially and gradually declined after vaccination or infection.
Blood donors, Seroprevalence, Sars-cov-2, Anti-n Igg, Anti-s Igg, Humans, Immunoglobulin G, Seroepidemiologic Studies, Adolescent, Adult, Aged, Middle Aged, Blood Donors, Austria, Female, Male, Young Adult, COVID-19, SARS-CoV-2
Tirol Kliniken GmbH (Not available)
Land Tirol (Not available)
External DOI: https://doi.org/10.3390/v14030568
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336438
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/