Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation
Authors
Hacker, Lina
Wabnitz, Heidrun
Pifferi, Antonio
Pfefer, T Joshua
Pogue, Brian W
Journal Title
Nature Biomedical Engineering
ISSN
2157-846X
Publisher
Nature Research
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Hacker, L., Wabnitz, H., Pifferi, A., Pfefer, T. J., Pogue, B. W., & Bohndiek, S. Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation. Nature Biomedical Engineering https://doi.org/10.17863/CAM.83907
Abstract
The reliability and reproducibility of experimental results are crucial in the development and regulatory approval of medical technologies, yet represent a challenge for biophotonic instrumentation due to a lack of accepted standards and phantoms suitable for successful technical validations. Here, we discuss the general design considerations for the preparation of tissue-mimicking biophotonic phantoms and then critically review the existing literature on phantom materials and fabrication across the field in light of these criteria and of recent developments at the state-of-the-art. We then focus on three representative examples of biophotonic standardisation related to different modalities, presented in order of their relative maturity: diffuse optical imaging and spectroscopy, fluorescence guided surgery, and photoacoustic imaging. Finally, we provide a perspective on future phantom development and the unmet needs of the biophotonic field, identifying a set of criteria, termed the “4Cs”, for biophotonic standardisation which highlight the need for characterisation, collaboration, communication and commitment to maximise the achievements of ongoing standardisation efforts.
Sponsorship
Cancer Research UK (C14303/A17197)
Cancer Research UK (C14303/A17197)
National Physical Laboratory (NPL) (unknown)
National Physical Laboratory (NPL) (unknown)
National Physical Laboratory (NPL) (unknown)
Embargo Lift Date
2025-04-26
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.83907
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336489
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