The unappreciated generative role of cell movements in pattern formation
Publication Date
2022-04-27Journal Title
Royal Society Open Science
Publisher
The Royal Society
Volume
9
Issue
4
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Fulton, T., Verd, B., & Steventon, B. (2022). The unappreciated generative role of cell movements in pattern formation. Royal Society Open Science, 9 (4) https://doi.org/10.1098/rsos.211293
Description
Funder: Herschel Smith Postdoctoral Fellowship
Funder: Vice Chancellor's Scholarship, Cambridge Trust
Abstract
The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
Keywords
Biochemistry, cellular and molecular biology, Review articles, cell movements, pattern formation, evolution of complex systems, evo-inspired engineering
Sponsorship
Wellcome Trust (109408/Z/15/Z)
Royal Society (109408/Z/15/Z)
Identifiers
rsos211293
External DOI: https://doi.org/10.1098/rsos.211293
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336501
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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