Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Authors
Hodzic-Santor, Benazir
Antoniades, Mathilde
Nenadic, Igor
Kircher, Tilo
Krug, Axel
Meller, Tina
Grotegerd, Dominik
Arnatkeviciute, Aurina
Koch, Katharina
Hülsmann, Carina
Enneking, Verena
Klug, Melissa
Leehr, Elisabeth J
Gruber, Marius
Mehler, David
Moyett, Ashley
Baune, Bernhard T
Green, Melissa
Quidé, Yann
Wang, Yi
Ettinger, Ulrich
Debbané, Martin
Derome, Melodie
Gaser, Christian
Besteher, Bianca
Diederen, Kelly
Spencer, Tom J
Fletcher, Paul
Rössler, Wulf
Smigielski, Lukasz
Premkumar, Preethi
Park, Haeme RP
Lemmers-Jansen, Imke
Gilleen, James
Allen, Paul
Kozhuharova, Petya
Marsman, Jan-Bernard
Lebedeva, Irina
Tomyshev, Alexander
Kaiser, Stefan
Fett, Anne-Kathrin
Sommer, Iris
Schuite-Koops, Sanne
Paquola, Casey
Bernhardt, Boris
Grant, Phillip
Thompson, Paul M
Aleman, André
Publication Date
2022-02Journal Title
Mol Psychiatry
ISSN
1359-4184
Publisher
Springer Science and Business Media LLC
Volume
27
Issue
2
Pages
1167-1176
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Kirschner, M., Hodzic-Santor, B., Antoniades, M., Nenadic, I., Kircher, T., Krug, A., Meller, T., et al. (2022). Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.. Mol Psychiatry, 27 (2), 1167-1176. https://doi.org/10.1038/s41380-021-01359-9
Abstract
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, pFDR = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, pspin = 0.024), but not BD (r = 0.166, pspin = 0.205) or MDD (r = -0.274, pspin = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, pspin = 0.006), BD (rho = -0.672, pspin = 0.009), and MDD (rho = -0.692, pspin = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.
Keywords
Article, /692/699/476/1799, /631/477, /59/57, article
Sponsorship
Wellcome Trust (Wellcome) (202397/Z/16/Z)
U.S. Department of Health & Human Services | National Institutes of Health (NIH) (EB020403)
Identifiers
s41380-021-01359-9, 1359
External DOI: https://doi.org/10.1038/s41380-021-01359-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336614
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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