Genetic correlates of phenotypic heterogeneity in autism.
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Authors
Zhang, Xinhe
Reed, Patrick
Cliquet, Freddy
Leblond, Claire S
Rolland, Thomas
EU-AIMS LEAP
iPSYCH-Autism Working Group
Spectrum 10K and APEX Consortia
Rowitch, David H
Robinson, Elise B
Publication Date
2022-06-02Journal Title
Nat Genet
ISSN
1061-4036
Publisher
Springer Science and Business Media LLC
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Warrier, V., Zhang, X., Reed, P., Havdahl, A., Moore, T. M., Cliquet, F., Leblond, C. S., et al. (2022). Genetic correlates of phenotypic heterogeneity in autism.. Nat Genet https://doi.org/10.1038/s41588-022-01072-5
Abstract
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (nmax = 12,893) based on core and associated features of autism, co-occurring developmental disabilities and sex. We conducted a comprehensive factor analysis of core autism features in autistic individuals and identified six factors. Common genetic variants were associated with the core factors, but de novo variants were not. We found that higher autism polygenic scores (PGS) were associated with lower likelihood of co-occurring developmental disabilities in autistic individuals. Furthermore, in autistic individuals without co-occurring intellectual disability (ID), autism PGS are overinherited by autistic females compared to males. Finally, we observed higher SNP heritability for autistic males and for autistic individuals without ID. Deeper phenotypic characterization will be critical in determining how the complex underlying genetics shape cognition, behavior and co-occurring conditions in autism.
Sponsorship
Wellcome Trust (214322/Z/18/Z)
Identifiers
External DOI: https://doi.org/10.1038/s41588-022-01072-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336780
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