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dc.contributor.authorFawcett, James W
dc.contributor.authorFyhn, Marianne
dc.contributor.authorJendelova, Pavla
dc.contributor.authorKwok, Jessica CF
dc.contributor.authorRuzicka, Jiri
dc.contributor.authorSorg, Barbara A
dc.date.accessioned2022-05-09T23:31:10Z
dc.date.available2022-05-09T23:31:10Z
dc.date.issued2022-06-27
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336961
dc.description.abstractAll components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition, some neurons, particularly inhibitory GABAergic parvalbumin-positive (PV) interneurons, are surrounded by a more condensed cartilage-like ECM called perineuronal nets (PNNs). PNNs surround the soma and proximal dendrites as net-like structures that surround the synapses. Attention has focused on the role of PNNs in the control of plasticity, but it is now clear that PNNs also play an important part in the modulation of memory. In this review we summarize the role of the ECM, particularly the PNNs, in the control of various types of memory and their participation in memory pathology. PNNs are now being considered as a target for the treatment of impaired memory. There are many potential treatment targets in PNNs, mainly through modulation of the sulphation, binding, and production of the various CSPGs that they contain or through digestion of their sulphated glycosaminoglycans.
dc.description.sponsorshipFunding for this research came from: Center of Reconstruction Neuroscience – NEURORECON CZ.02.1.01/0.0/0.0/15_003/0000419 and Czech Science Agency 19-10365S. Medical Research Council MR/R004463, MR/V002694, Wings for Life (WFL-GB-04/19), IRP P172 to JWF. Epilepsy Research UK (P1807), Alzheimer’s Research UK, Wings for Life (WFL-UK-008-15), COST Action INNOGLY (CA18103) to JCFK. Good Samaritan Foundation of Legacy Health, and National Institutes of Health DA040965 and DA047121 to BAS.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleThe extracellular matrix and perineuronal nets in memory.
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2022-05-09T14:52:01Z
prism.publicationNameMol Psychiatry
dc.identifier.doi10.17863/CAM.84384
dcterms.dateAccepted2022-05-16
rioxxterms.versionofrecord10.1038/s41380-022-01634-3
rioxxterms.versionAM
dc.contributor.orcidFawcett, James W [0000-0002-7990-4568]
dc.contributor.orcidJendelova, Pavla [0000-0002-4644-9212]
dc.contributor.orcidKwok, Jessica CF [0000-0002-9798-9083]
dc.contributor.orcidRuzicka, Jiri [0000-0002-1269-1633]
dc.contributor.orcidSorg, Barbara A [0000-0002-4913-4910]
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R004544/1)
pubs.funder-project-idMedical Research Council (MR/R004463/1)
pubs.funder-project-idMRC (MR/V002694/1)
cam.issuedOnline2022-06-27
cam.orpheus.successMon Jul 11 08:50:16 BST 2022 - Embargo updated
cam.orpheus.counter6
cam.depositDate2022-05-09
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-12-27


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