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dc.contributor.authorFawcett, James
dc.contributor.authorKwok, Jessica
dc.contributor.authorRuzicka, Jiri
dc.contributor.authorJendelova, Pavla
dc.contributor.authorFyhn, Marianne
dc.contributor.authorSorg, Barbara
dc.date.accessioned2022-05-09T23:31:10Z
dc.date.available2022-05-09T23:31:10Z
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336961
dc.description.abstractPerineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store, and that they which remains stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage.
dc.description.sponsorshipFunding for this research came from: Center of Reconstruction Neuroscience – NEURORECON CZ.02.1.01/0.0/0.0/15_003/0000419 and Czech Science Agency 19-10365S. Medical Research Council MR/R004463, MR/V002694, Wings for Life (WFL-GB-04/19), IRP P172 to JWF. Epilepsy Research UK (P1807), Alzheimer’s Research UK, Wings for Life (WFL-UK-008-15), COST Action INNOGLY (CA18103) to JCFK. Good Samaritan Foundation of Legacy Health, and National Institutes of Health DA040965 and DA047121 to BAS.
dc.publisherSpringer Nature [academic journals on nature.com]
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleTHE EXTRACELLULAR MATRIX AND PERINEURONAL NETS IN MEMORY
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2022-05-09T14:52:01Z
prism.publicationNameMolecular Psychiatry
dc.identifier.doi10.17863/CAM.84384
dcterms.dateAccepted2022-05-04
rioxxterms.versionAM
dc.contributor.orcidFawcett, James [0000-0002-7990-4568]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R004544/1)
cam.orpheus.counter4*
cam.depositDate2022-05-09
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2025-05-09


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