Primary Lymphomas of the Breast: A Review.
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Authors
James, Emily R
Miranda, Roberto N
Turner, Suzanne D
Publication Date
2022-06Journal Title
JPRAS Open
ISSN
2352-5878
Publisher
Elsevier BV
Volume
32
Pages
127-143
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
James, E. R., Miranda, R. N., & Turner, S. D. (2022). Primary Lymphomas of the Breast: A Review.. JPRAS Open, 32 127-143. https://doi.org/10.1016/j.jpra.2022.01.004
Abstract
Lymphomas of the breast are rare neoplasms that arise from breast lymphoid tissue and are characterised by neoplastic B or T cells. Breast lymphomas arising from B cells include, but are not limited to, diffuse large B cell lymphoma, follicular lymphoma, extra-nodal marginal zone lymphoma and Burkitt lymphoma. Anaplastic large cell lymphoma (ALCL) is of a T cell origin and both anaplastic lymphoma kinase (ALK)-positive and ALK-negative presentations have been noted in the breast. In addition, there is a more recently identified presentation of ALK-negative ALCL that arises around textured breast implants and is usually confined to a periprosthetic fibrous capsule. Here, we discuss the clinical presentations, histological and immunohistochemical features and treatment options for each type of primary breast lymphoma. We hope that this review will highlight the importance of the timely and accurate diagnosis of breast lymphoma in order to tailor the most appropriate treatment. We also wish to raise awareness of the breast implant-associated lymphomas, with the goal of stimulating work that will aid our understanding of their epidemiology and pathogenesis.
Keywords
Non-hodgkin Lymphoma, Breast Implants, Breast Lymphoma, Bia-alcl, Breast Implant Lymphoma
Identifiers
35402679, PMC8987598
External DOI: https://doi.org/10.1016/j.jpra.2022.01.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337060
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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