Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.
J Autism Dev Disord
Springer Science and Business Media LLC
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Ng-Cordell, E., Kolesnik-Taylor, A., O'Brien, S., Astle, D., Scerif, G., & Baker, K. (2022). Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.. J Autism Dev Disord, 1-12. https://doi.org/10.1007/s10803-022-05527-w
DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.
Anxiety, Autism, DDX3X, Intellectual disability, Self-injurious behaviour
External DOI: https://doi.org/10.1007/s10803-022-05527-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337581
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/