Deep-Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Paterson, I https://orcid.org/0000-0002-8861-9136
Abstract
jats:titleAbstract</jats:title>jats:pThe marine natural product hemicalide displays potent anticancer activity. While detailed NMR experiments established the planar carbon skeleton, its full configurational assignment proved enigmatic. This Review summarises ongoing synthetic efforts and NMR studies on hemicalide, which have succeeded in reducing the number of possible stereoisomers from more than one million to a more manageable eight structures, setting the stage for a focused total synthesis campaign.</jats:p>
Description
Funder: Woolf Fisher
Funder: Trinity Hall
Keywords
Configuration determination, Natural products, NMR spectroscopy, Structure elucidation, Total synthesis
Journal Title
European Journal of Organic Chemistry
Conference Name
Journal ISSN
1434-193X
1099-0690
1099-0690
Volume Title
Publisher
Wiley