Mapping the developing human immune system across organs.
American Association for the Advancement of Science (AAAS)
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Suo, C., Dann, E., Goh, I., Jardine, L., Kleshchevnikov, V., Park, J., Botting, R. A., et al. (2022). Mapping the developing human immune system across organs.. Science https://doi.org/10.1126/science.abo0510
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.
Lymphocytes, Monocytes, Immune System, Humans, Genomics, Organ Specificity, Single-Cell Analysis, RNA-Seq
Medical Research Council (MR/S035842/1)
External DOI: https://doi.org/10.1126/science.abo0510
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338047
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/