Mapping the developing human immune system across organs.
American Association for the Advancement of Science (AAAS)
MetadataShow full item record
Suo, C., Dann, E., Goh, I., Jardine, L., Kleshchevnikov, V., Park, J., Botting, R. A., et al. (2022). Mapping the developing human immune system across organs.. Science https://doi.org/10.1126/science.abo0510
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.
Genomics, Humans, Immune System, Lymphocytes, Monocytes, Organ Specificity, RNA-Seq, Single-Cell Analysis
Medical Research Council (MR/S035842/1)
External DOI: https://doi.org/10.1126/science.abo0510
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338047
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org