The unappreciated generative role of cell movements in pattern formation.
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Publication Date
2022-04-27Journal Title
Royal Society open science
ISSN
2054-5703
Volume
9
Issue
4
Language
eng
Type
Article
This Version
VoR
Metadata
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Fulton, T., Verd, B., & Steventon, B. (2022). The unappreciated generative role of cell movements in pattern formation.. Royal Society open science, 9 (4) https://doi.org/10.1098/rsos.211293
Abstract
The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
Keywords
pattern formation, Cell Movements, Evo-inspired Engineering, Evolution Of Complex Systems
Sponsorship
Wellcome Trust (109408/Z/15/Z)
Identifiers
35601454, PMC9043703
External DOI: https://doi.org/10.1098/rsos.211293
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338567
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