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dc.contributor.authorThiruppathy, Mathi
dc.contributor.authorFabian, Peter
dc.contributor.authorGillis, James
dc.contributor.authorCrump, J Gage
dc.date.accessioned2022-06-29T19:50:14Z
dc.date.available2022-06-29T19:50:14Z
dc.date.issued2022-06-28
dc.date.submitted2022-02-25
dc.identifier.issn2050-084X
dc.identifier.other78170
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338602
dc.description.abstractWhereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.subjectShort Report
dc.subjectDevelopmental Biology
dc.subjectEvolutionary Biology
dc.subjectPseudobranch
dc.subjectGill
dc.subjectjaw
dc.subjectmandibular arch
dc.subjectcranial neural crest
dc.subjectZebrafish
dc.titleGill developmental program in the teleost mandibular arch.
dc.typeArticle
dc.date.updated2022-06-29T19:50:14Z
prism.publicationNameElife
prism.volume11
dc.identifier.doi10.17863/CAM.86015
dcterms.dateAccepted2022-05-28
rioxxterms.versionofrecord10.7554/eLife.78170
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: LaBonne, Carole
datacite.contributor.supervisorsenior_editor: Bronner, Marianne E
dc.contributor.orcidThiruppathy, Mathi [0000-0002-6337-3256]
dc.contributor.orcidGillis, James [0000-0003-2062-3777]
dc.contributor.orcidCrump, J Gage [0000-0002-3209-0026]
dc.identifier.eissn2050-084X
pubs.funder-project-idNational Institute of Dental and Craniofacial Research (5R35DE027550)
pubs.funder-project-idNational Institute of Dental and Craniofacial Research (5K99DE029858)
pubs.funder-project-idNational Institute of Dental and Craniofacial Research (1F31DE030706)
pubs.funder-project-idRoyal Society (UF130182)
pubs.funder-project-idRoyal Society (URF\R\191007)
cam.issuedOnline2022-06-28


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