Genomic evolution of cancer metastasis under therapeutic pressure
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Peer-reviewed
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Abstract
jats:titleAbstract</jats:title>jats:pIn the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed over the disease course of a patient with metastatic cancer. A large‐scale study investigates the genomic evolution of cancer metastases under therapeutic pressure and finds that the actionable genome has remained relatively stable. The findings support the sufficiency of a single biopsy of cancer metastasis for therapeutic decision‐making.</jats:p>
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Keywords
31 Biological Sciences, 32 Biomedical and Clinical Sciences, 3105 Genetics, 3211 Oncology and Carcinogenesis, Cancer, Genetics, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, 2 Aetiology, Cancer, 3 Good Health and Well Being
Journal Title
MedComm – Oncology
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Journal ISSN
2769-6448
2769-6448
2769-6448
Volume Title
1
Publisher
Wiley
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Sponsorship
National Natural Science Foundation of China (82073246)
Sichuan Science and Technology Programme (2022JDRC0049)
Sichuan Science and Technology Programme (2022JDRC0049)