Transferability of genetic risk scores in African populations.
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Authors
Kamiza, Abram B
Toure, Sounkou M
Soremekun, Opeyemi S
Kintu, Christopher
Pirie, Fraser
Young, Elizabeth
Sandhu, Manjinder S
Kaleebu, Pontiano
Motala, Ayesha A
Publication Date
2022-06-02Journal Title
Nature medicine
ISSN
1078-8956
Volume
28
Issue
6
Pages
1163-1166
Language
eng
Type
Article
This Version
VoR
Metadata
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Kamiza, A. B., Toure, S. M., Vujkovic, M., Machipisa, T., Soremekun, O. S., Kintu, C., Corpas, M., et al. (2022). Transferability of genetic risk scores in African populations.. Nature medicine, 28 (6), 1163-1166. https://doi.org/10.1038/s41591-022-01835-x
Abstract
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and multiancestry data perform better in sub-Saharan Africa (SSA) compared to European ancestry-derived scores. Using summary statistics from the Million Veteran Program (MVP), we showed that GRSs derived from data of African American individuals enhance polygenic prediction of lipid traits in SSA compared to European and multiancestry scores. However, our GRS prediction varied greatly within SSA between the South African Zulu (low-density lipoprotein cholesterol (LDL-C), R<sup>2</sup> = 8.14%) and Ugandan cohorts (LDL-C, R<sup>2</sup> = 0.026%). We postulate that differences in the genetic and environmental factors between these population groups might lead to the poor transferability of GRSs within SSA. More effort is required to optimize polygenic prediction in Africa.
Keywords
Humans, Risk Factors, Population Groups, Cholesterol, LDL, Genome-Wide Association Study, Blacks
Sponsorship
Wellcome Trust (220740/Z/20/Z, 214205/Z/18/Z)
U.S. Department of Health & (1U01HG011717)
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) (1U01HG011717)
British Heart Foundation (RE/18/4/34215)
Identifiers
PMC9205766, 35654908
External DOI: https://doi.org/10.1038/s41591-022-01835-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338723
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