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A Year at the Forefront of Proteostasis and Aging.

Published version
Peer-reviewed

Change log

Authors

Thompson, Maximilian A  ORCID logo  https://orcid.org/0000-0003-1349-4735
De-Souza, Evandro A  ORCID logo  https://orcid.org/0000-0002-9080-3864

Abstract

During aging, animals experience a decline in proteostasis activity, including loss of stress-response activation, culminating in the accumulation of misfolded proteins and toxic aggregates, which are causal in the onset of some chronic diseases. Finding genetic and pharmaceutical treatments that can increase organismal proteostasis and lengthen life is an ongoing goal of current research. The regulation of stress responses by cell non-autonomous mechanisms appears to be a potent way to impact organismal healthspan. In this Review, we cover recent findings in the intersection of proteostasis and aging, with a special focus on articles and preprints published between November 2021 and October 2022. A significant number of papers published during this time increased our understanding of how cells communicate with each other during proteotoxic stress. Finally, we also draw attention to emerging datasets that can be explored to generate new hypotheses that explain age-related proteostasis collapse.

Description

Peer reviewed: True


Funder: Medical Research Council

Journal Title

Biol Open

Conference Name

Journal ISSN

2046-6390
2046-6390

Volume Title

Publisher

The Company of Biologists

Rights and licensing

Except where otherwised noted, this item's license is described as http://creativecommons.org/licenses/by/4.0
Sponsorship
European Union's Horizon 2020 research and innovation programme (894039)