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Mapping SARS-CoV-2 antigenic relationships and serological responses

Accepted version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/358062

Repository DOI

https://doi.org/10.17863/CAM.101899
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Primary Accepted version (491.43 KB)

Type

Article

Change log

Authors

Smith, Derek J  ORCID logo  https://orcid.org/0000-0002-2393-1890
Wilks, Samuel H  ORCID logo  https://orcid.org/0000-0002-7760-8474
Netzl, Antonia  ORCID logo  https://orcid.org/0000-0001-8034-2382

Abstract

Vaccination has greatly reduced the disease burden of SARS-CoV-2. However, since late 2020, variants have emerged that are able to escape immunity from vaccination and previous infections, including B.1.351 (Beta), P.1 (Gamma), B.1.617.2 (Delta), and B.1.1.529 (Omicron and its descendants). In combination with vaccination, infections with different variants form the basis of current population immunity against SARS-CoV-2.

Description

Keywords

Humans, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Cross Reactions, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Antigens, Viral, mRNA Vaccines, Vaccination, Amino Acid Substitution

Journal Title

Science

Conference Name

Journal ISSN

0036-8075
1095-9203

Volume Title

Publisher

American Association for the Advancement of Science (AAAS)

Publisher DOI

https://doi.org/10.1126/science.adj0070

Rights and licensing

Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International
Sponsorship
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (Option 18B)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-C504-4612)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-B504-4612)

Relationships

Is derived from:
https://doi.org/10.1101/2022.01.28.477987

Collections

University of Cambridge Research Outputs (Articles and Conferences)