Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.
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Peer-reviewed
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Authors
Giotis, Efstathios S
Young, Erik F
Ghanny, Saleena
Soteropoulos, Patricia
Abstract
Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.
Description
Keywords
Animals, Chiroptera, Dogs, HEK293 Cells, HLA-DR Antigens, Humans, Madin Darby Canine Kidney Cells, Microarray Analysis, Orthomyxoviridae, Receptors, Virus, Viral Tropism, Virus Internalization, Zoonoses
Journal Title
Nature Microbiology
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Journal ISSN
2058-5276
2058-5276
2058-5276
Volume Title
4
Publisher
Nature Research
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