Impact of hybrid closed-loop insulin delivery on cardiac rhythm in older adults with type 1 diabetes: A post hoc analysis of trial data.

Abstract

People with type 1 diabetes (T1D) are at higher risks from CVD and cardiac arrhythmia when compared to people without diabetes, and these risks increase with age1. T1D is also associated with a higher risks from sudden cardiac death, which may be up to 10-fold higher than the background population2. Growing evidence indicates that glycaemic excursions, specifically hypoglycaemia, have a causal role in precipitating cardiovascular events, arrythmias and increasing mortality risk3,4. The higher vulnerability of people with T1D to hypoglycaemia-induced arrythmia appears to persist, even following recovery from hypoglycaemia5. Observational and experimental studies have found that dysglycaemia increases the risk of ventricular arrythmias and pro-arrhythmic repolarization abnormalities such as QTc-interval prolongation5.