Detecting alpha-synuclein aggregates with small molecules on single-molecule array
Published version
Peer-reviewed
Repository URI
Repository DOI
Loading...
Type
Change log
Authors
Abstract
A new assay leverages the small molecule BF-79-2, instead of antibodies, to specifically capture and detect α-synuclein aggregates at picomolar levels in biofluids, enhancing versatility for biomarker disease diagnostics.
Description
Acknowledgements: We thank Dorothea Böken, Emre Fertan, and Jason C. Sang for their technical support. We also thank Swapan Preet and Ewa Klimont (Cambridge Centre for Misfolding Diseases) for the expression and purification of α-synuclein. This work was supported by Michael J. Fox Foundation (MJFF-020701) and a grant from the UK Dementia Research Institute (which receives its funding from UK DRI Ltd). J. Y. L. L. was supported by the Croucher Foundation Limited (Hong Kong).
Publication status: Published
Keywords
Journal Title
Chemical Science
Conference Name
Journal ISSN
2041-6520
2041-6539
2041-6539
Volume Title
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Rights and licensing
Except where otherwised noted, this item's license is described as https://creativecommons.org/licenses/by/3.0/
Sponsorship
Michael J. Fox Foundation for Parkinson's Research (MJFF-020701)
Croucher Foundation (Unassigned)
UK Dementia Research Institute (Unassigned)
Croucher Foundation (Unassigned)
UK Dementia Research Institute (Unassigned)