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Case report: Allogeneic stem cell transplantation for type B insulin resistance

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Ebert, Thomas 
Behre, Gerhard 
Weidhase, Lorenz 
Vucinic, Vladan 
Gewert, Cornelia 


Type B insulin resistance (TBIR) is a rare, often fulminant form of insulin resistance caused by autoantibodies against the insulin receptor. If left untreated, its mortality is high. Various immunosuppressive regimens have shown efficacy, but treatment effects are variable and time-delayed, and drug-induced complications may arise. We report a patient with TBIR arising as a complication of Wiskott–Aldrich syndrome. Stable remission of TBIR was achieved through allogeneic peripheral blood stem cell transplantation (PBSCT) over a follow-up period of more than 1.5 years. We thus demonstrate that PBSCT can be considered a treatment option in TBIR where conventional immunosuppressive therapy is ineffective or contraindicated.


Peer reviewed: True

Acknowledgements: We would like to thank Susette I. Unger, Matthias Pierer, and Jan Halbritter (University of Leipzig Medical Center, Medical Department III, Divisions of Nephrology and Rheumatology, Leipzig, Germany), Sirak Petros (University of Leipzig Medical Center, Medical Intensive Care Unit), Dietger Niederwieser (University of Leipzig Medical Center, Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig, Germany), and Christoph Lübbert (University of Leipzig Medical Center, Division of Infectious Diseases and Tropical Medicine, Department of Medicine II, and Interdisciplinary Center for Infectious Diseases, Leipzig, Germany) for their excellent support throughout the treatment course of the patient.


allogeneic peripheral blood stem cell transplantation, case report, diabetes, rescue therapy, Wiskott-Aldrich syndrome, type B insulin resistance

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