Photoactivated release of membrane impermeant sulfonates inside cells.


Type
Article
Change log
Authors
Abstract

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

Description
Keywords
Anions, Cell Membrane Permeability, Coumarins, HeLa Cells, Humans, Phosphates, Photochemical Processes, Rhodamines, Sulfonic Acids
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
Volume Title
57
Publisher
Royal Society of Chemistry (RSC)
Sponsorship
Medical Research Council (MC_U105663142)
Wellcome Trust (110159/Z/15/Z)
Wellcome Trust (203934/Z/16/Z)