Longitudinal associations between prepubertal childhood total energy and macronutrient intakes and subsequent puberty timing in UK boys and girls.


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Authors
Sharp, Stephen J 
Brage, Soren 
Emmett, Pauline M 
Forouhi, Nita G 
Abstract

PURPOSE: Early puberty is associated with adverse health outcomes. To identify potential modifiable factors for puberty timing, we examined the associations of prepubertal childhood macronutrient intakes with puberty timing in boys and girls. METHODS: In the Avon Longitudinal Study of Parents and Children, macronutrient intakes at age 6 years were predicted using random intercepts linear regression models of dietary data at 3, 4, 7 (assessed by food frequency questionnaires) and 7.5 years (by 3-day food diaries). Timings of puberty onset (Tanner stage 2 genital or breast (B2) development) and puberty completion (voice breaking (VB) or menarche) were calculated from annual parental and child reports at 8-17 years. Age at peak height velocity (PHV) was derived from repeated height measurements at 5-20 years. Linear regression models were fit to estimate the associations of total energy (TEI) and macronutrient intakes (carbohydrate, fat, protein) with puberty timing traits, adjusting for maternal and infant characteristics. RESULTS: Among 3811 boys, higher TEI, but no macronutrient, was associated with earlier VB. Among 3919 girls, higher TEI was associated with earlier ages at B2, PHV, and menarche. Higher protein intake but not carbohydrate or fat intake (in energy partition models) and substitution of dietary protein for carbohydrate (in nutrient density and residual models) was associated with earlier B2, PHV, and menarche in girls. Findings were not attenuated on additional adjustment for body fat percentage during adolescence. CONCLUSIONS: These findings suggest habitual total energy intakes in children, and protein intakes in girls, as potential modifiable determinants of puberty timing.

Description

Funder: the NIHR Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme; Grant(s): IS-BRC-1215-20014

Keywords
ALSPAC, Dietary intake, Prospective study, Protein, Puberty timing, Random intercepts model, Child, Eating, Female, Humans, Longitudinal Studies, Male, Menarche, Puberty, United Kingdom
Journal Title
Eur J Nutr
Conference Name
Journal ISSN
1436-6207
1436-6215
Volume Title
61
Publisher
Springer Science and Business Media LLC
Sponsorship
MRC (MC_UU_00006/2)
Medical Research Council (MC_UU_12015/5)
MRC (UD99999971)
Department of Health (via National Institute for Health Research (NIHR)) (NIHR202397)
MRC (MC_UU_00006/4)
MRC (MC_UU_00006/3)
National Institute for Health and Care Research (IS-BRC-1215-20014)