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Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera.

Published version
Peer-reviewed

Repository DOI


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Authors

Knabl, Ludwig 
Wilks, Samuel H 
Mühlemann, Barbara 

Abstract

Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.

Description

Acknowledgements: We thank Albert Falch and Verena Pittl for their excellent technical support. The NIH NIAID Centers of Excellence for Influenza Research and Response (CEIRR) contract 75N93021C00014 as part of the SAVE program supported JK, DJS, BLH, AN, SHW, and ST. AN was supported by the Gates Cambridge Trust. The European Union’s Horizon 2020 research and innovation program under grant agreement No. 101016174 and the Austrian Science Fund (FWF) with the project number P35159-B supported JK.


Funder: Gates Cambridge Trust; doi: https://doi.org/10.13039/501100005370

Keywords

3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, 3204 Immunology, Vaccine Related, Prevention, Biotechnology, Immunization, Emerging Infectious Diseases, Clinical Research, 3 Good Health and Well Being

Journal Title

NPJ Vaccines

Conference Name

Journal ISSN

2059-0105
2059-0105

Volume Title

9

Publisher

Springer Science and Business Media LLC
Sponsorship
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) (75N93021C00014, 75N93021C00014, 75N93021C00014, 75N93021C00014, 75N93021C00014, 75N93021C00014)
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) (101016174)
Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) (P35159-B)