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Association of gout with brain reserve and vulnerability to neurodegenerative disease.

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Mankia, Kulveer 
Webb, Alastair 


Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.



5202 Biological Psychology, 42 Health Sciences, 52 Psychology, Aging, Parkinson's Disease, Dementia, Alzheimer's Disease, Neurosciences, Clinical Research, Acquired Cognitive Impairment, Neurodegenerative, Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, 2.1 Biological and endogenous factors, 2 Aetiology, Neurological, Humans, Neurodegenerative Diseases, Cognitive Reserve, Gout, Brain, Dementia

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Nat Commun

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Nature Portfolio
Wellcome Trust (204623/Z/16/Z)
British Heart Foundation (RG/16/4/32218)
National Institute for Health and Care Research (IS-BRC-1215-20014)