Extending DerSimonian and Laird's methodology to perform network meta-analyses with random inconsistency effects.
Change log
Authors
Jackson, Dan
Barrett, Jessica K
Turner, Rebecca
Higgins, Julian PT
Abstract
Network meta-analysis is becoming more popular as a way to compare multiple treatments simultaneously. Here, we develop a new estimation method for fitting models for network meta-analysis with random inconsistency effects. This method is an extension of the procedure originally proposed by DerSimonian and Laird. Our methodology allows for inconsistency within the network. The proposed procedure is semi-parametric, non-iterative, fast and highly accessible to applied researchers. The methodology is found to perform satisfactorily in a simulation study provided that the sample size is large enough and the extent of the inconsistency is not very severe. We apply our approach to two real examples.
Description
Keywords
method of moments, mixed treatment comparisons, multiple treatments meta-analysis, network meta-analysis, Anti-Bacterial Agents, Arthralgia, Bayes Theorem, Clinical Trials as Topic, Computer Simulation, Humans, Meta-Analysis as Topic, Models, Statistical, Osteoarthritis, Knee, Otitis Media with Effusion, Probability, Regression Analysis, Sample Size, Tympanic Membrane Perforation, Uncertainty
Journal Title
Stat Med
Conference Name
Journal ISSN
0277-6715
1097-0258
1097-0258
Volume Title
35
Publisher
Wiley
Publisher DOI
Sponsorship
MRC (MR/L501566/1)
Medical Research Council (MR/K014811/1)
Medical Research Council (MR/L003120/1)
National Institute for Health Research (NIHR) (via Royal Brompton & Harefield NHS Foundation Trust) (unknown)
British Heart Foundation (None)
Medical Research Council (MR/K014811/1)
Medical Research Council (MR/L003120/1)
National Institute for Health Research (NIHR) (via Royal Brompton & Harefield NHS Foundation Trust) (unknown)
British Heart Foundation (None)
DJ, RT and IRW are employed by the UK Medical Research Council (code U105260558). JB is supported by the UK MRC grant numbers G0902100 and MR/K014811/1.