jats:titleAbstract</jats:title> jats:pThe Astropy Project supports and fosters the development of open-source and openly developed jats:monospacePython</jats:monospace> packages that provide commonly needed functionality to the astronomical community. A key element of the Astropy Project is the core package jats:monospaceastropy</jats:monospace>, which serves as the foundation for more specialized projects and packages. In this article, we summarize key features in the core package as of the recent major release, version 5.0, and provide major updates on the Project. We then discuss supporting a broader ecosystem of interoperable packages, including connections with several astronomical observatories and missions. We also revisit the future outlook of the Astropy Project and the current status of Learn Astropy. We conclude by raising and discussing the current and future challenges facing the Project.</jats:p>