Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology


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Authors
Nazir, Mamona 
Saleem, Muhammad 
Tousif, Muhammad Imran  ORCID logo  https://orcid.org/0000-0002-5777-6112
Anwar, Muhammad Aijaz 
Abstract

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

Description
Keywords
meroterpenoids, structural diversity, antidiabetic, anticancer, antioxidant, anti-inflammatory
Journal Title
Biomolecules
Conference Name
Journal ISSN
2218-273X
Volume Title
11
Publisher
MDPI
Sponsorship
This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program (-----)