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Effect of the Graphene- Ni/NiFe2O4 Composite on Bacterial Inhibition Mediated by Protein Degradation.

Published version
Peer-reviewed

Type

Article

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Authors

Satyanarayana Acharyulu, Narayanam Phani 
Sohan, Arya 
Banoth, Pravallika 
Chintalapati, Srinivasu 
Doshi, Sejal 

Abstract

Recent investigations have demonstrated that nickel ferrite nanoparticles and their derivatives have toxicity effects on bacterial cells. In this study, we have prepared nickel ferrite nanoparticles (Ni/NiFe2O4) and nickel/nickel ferrite graphene oxide (Ni/NiFe2O4-GO) nanocomposite and evaluated their toxic effects on E. coli cells ATCC 25922. The prepared nanomaterials were characterized using X-ray diffraction, Raman spectroscopy, scanning electron microscopy, transmission electron microscopy, and vibrating sample magnetometry techniques. The toxicity was evaluated using variations in cell viability, cell morphology, protein degradation, and oxidative stress. Ni/NiFe2O4-GO nanocomposites likewise prompt oxidative stress proved by the age of reactive oxygen species (ROS) and exhaustion of antioxidant glutathione. This is the first report indicating that Ni/NiFe2O4-GO nanocomposite-initiated cell death in E. coli through ROS age and oxidative stress.

Description

Keywords

40 Engineering, 4018 Nanotechnology, Bioengineering, Nanotechnology

Journal Title

ACS Omega

Conference Name

Journal ISSN

2470-1343
2470-1343

Volume Title

7

Publisher

American Chemical Society (ACS)