The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.

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cam.issuedOnline2022-02-09
dc.contributor.authorSiripanthong, Bhurint
dc.contributor.authorAsatryan, Babken
dc.contributor.authorHanff, Thomas C
dc.contributor.authorChatha, Salman R
dc.contributor.authorKhanji, Mohammed Y
dc.contributor.authorRicci, Fabrizio
dc.contributor.authorMuser, Daniele
dc.contributor.authorFerrari, Victor A
dc.contributor.authorNazarian, Saman
dc.contributor.authorSantangeli, Pasquale
dc.contributor.authorDeo, Rajat
dc.contributor.authorCooper, Leslie T
dc.contributor.authorMohiddin, Saidi A
dc.contributor.authorChahal, C Anwar A
dc.contributor.orcidAsatryan, Babken [0000-0002-0050-5717]
dc.contributor.orcidChatha, Salman R [0000-0001-8595-8936]
dc.date.accessioned2022-03-19T02:05:47Z
dc.date.available2022-03-19T02:05:47Z
dc.date.issued2022-03
dc.date.updated2022-03-19T02:05:47Z
dc.description.abstractThe mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
dc.identifier.doi10.17863/CAM.82624
dc.identifier.eissn2452-302X
dc.identifier.issn2452-302X
dc.identifier.other35165665
dc.identifier.otherPMC8828362
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335194
dc.languageeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.jacbts.2021.10.011
dc.sourceessn: 2452-302X
dc.sourcenlmid: 101677259
dc.subjectCMR, cardiovascular magnetic resonance
dc.subjectCOVID-19
dc.subjectCOVID-19, coronavirus disease-2019
dc.subjectCT, Computerized Tomography
dc.subjectLGE, late gadolinium enhancement
dc.subjectMI, myocardial infarction
dc.subjectSARS-CoV-2, severe acute respiratory syndrome coronavirus-2
dc.subjectathlete
dc.subjectcardiovascular magnetic resonance imaging
dc.subjectinflammation
dc.subjectmyocardial injury
dc.subjectmyocarditis
dc.subjectsudden cardiac death
dc.subjecttroponin
dc.titleThe Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.
dc.typeArticle
dcterms.dateAccepted2021-10-20
prism.publicationNameJACC Basic Transl Sci
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.jacbts.2021.10.011
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