Deprivation and prognosis in patients with Pulmonary Arterial Hypertension: missing the effect of deprivation on a rare disease?

Change log
Eleni, Sofianopoulou 
Colin, Church 
Gerry, Coghlan 

In this journal, Pellino et al presented survival analysis to assess how deprivation affects prognosis in patients with pulmonary arterial hypertension (PAH)1. Their conclusions were that social deprivation is not a significant referral barrier or prognostic factor for idiopathic (I)PAH or heritable (H)PAH in Scotland. This may appear surprising given the wider context of literature describing outcomes stratified by social deprivation. The authors were thorough on using both the address at time of diagnosis and at time of censoring to assign deprivation scores and compare the two, finding no significant differences between the two approaches. They also compared deprivation assigned to PAH cases to expected deprivation based on Scottish citizenry as a whole and found that PAH patients are more socially deprived than expected. Finally, they used the same survival univariate analysis adjusting for age and sex to assess how several clinical variables are associated with prognosis.

Familial Primary Pulmonary Hypertension, Humans, Prognosis, Pulmonary Arterial Hypertension, Rare Diseases, Scotland
Journal Title
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
Conference Name
Journal ISSN
Volume Title
European Respiratory Society
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
British Heart Foundation (None)
Medical Research Council (MR/K020919/1)
British Heart Foundation (SP/18/10/33975)