Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality


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Authors
Arntz, Fréderique E. 
Yellowlees, Robyn 
Cardinal, Rudolf N.  ORCID logo  https://orcid.org/0000-0002-8751-5167
Price, Annabel 
Abstract

Abstract: Serotonin is involved in a wide range of mental capacities essential for navigating the social world, including emotion and impulse control. Much recent work on serotonin and social functioning has focused on decision-making. Here we investigated the influence of serotonin on human emotional reactions to social conflict. We used a novel computerised task that required mentally simulating social situations involving unjust harm and found that depleting the serotonin precursor tryptophan—in a double-blind randomised placebo-controlled design—enhanced emotional responses to the scenarios in a large sample of healthy volunteers (n = 73), and interacted with individual differences in trait personality to produce distinctive human emotions. Whereas guilt was preferentially elevated in highly empathic participants, annoyance was potentiated in those high in trait psychopathy, with medium to large effect sizes. Our findings show how individual differences in personality, when combined with fluctuations of serotonin, may produce diverse emotional phenotypes. This has implications for understanding vulnerability to psychopathology, determining who may be more sensitive to serotonin-modulating treatments, and casts new light on the functions of serotonin in emotional processing.

Description

Funder: Gates Cambridge Trust; doi: https://doi.org/10.13039/501100005370

Keywords
Article, /631/477/2811, /692/53/2423, article
Journal Title
Translational Psychiatry
Conference Name
Journal ISSN
2158-3188
Volume Title
11
Publisher
Nature Publishing Group UK
Sponsorship
Wellcome Trust (Wellcome) (104631/Z/14/Z)